The research project “Unlocking the Muse” at the University of Vienna explores the connection between art, creativity, and Parkinson’s disease. The project aims to understand how creativity impacts individuals with Parkinson’s and vice versa. This project unites an international and interdisciplinary consortium of art researchers and neuroscientists investigating changes in creativity among Parkinson’s patients, with initial findings suggesting shifts in creative interest post-diagnosis. Utilizing neuroimaging techniques, they aim to target specific brain regions associated with creativity to further understand this relationship. Cognitive flexibility, a key aspect of creativity, is also being examined, with implications for both disease development and prevention. Challenges include the diverse nature of Parkinson’s symptoms and the need for complex study designs. The interdisciplinary approach and collaboration with Parkinson’s patients themselves underscore the project’s breadth and depth, highlighting the multifaceted nature of both the disease and the research efforts.